I do, however, wonder why so many people experiencing melancholia are now taking pills simply to ease the pain. Of course there is a fine line between what I’m calling melancholia and what society calls depression. In my mind, what separates the two is degree of activity. Both forms are more or less chronic sadness that leads to continuing unease with how things are – persistent feelings that the world is not quite right, that it is a place of suffering, stupidity, and evil. Depression (as I see it, at least) causes apathy in the face of this unease, lethargy approaching total paralysis, an inability to feel much of anything one way or another. In contrast, melancholia generates a deep feeling in regard to this same anxiety, a turbulence of heart that results in an active questioning of the status quo, a perpetual longing to create new ways of being and seeing.
—Eric G. Wilson, “In Praise of Melancholy”